Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying enzymes and antioxidant stress proteins in response to electrophilic agents and oxidative stress. In the absence of such stimuli, Nrf2 is inactive owing to its cytoplasmic retention by Keap1 and rapid degradation th...

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Bibliographische Detailangaben
Hauptverfasser: Kobayashi, Akira, Kang, Moon-Il, Okawa, Hiromi, Ohtsuji, Makiko, Zenke, Yukari, Chiba, Tomoki, Igarashi, Kazuhiko, Yamamoto, Masayuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Transcriptional Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC479737/
https://ncbi.nlm.nih.gov/pubmed/15282312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.16.7130-7139.2004
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