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Hydroxymethyluracil modifications enhance the flexibility and hydrophilicity of double-stranded DNA
Oxidation of a DNA thymine to 5-hydroxymethyluracil is one of several recently discovered epigenetic modifications. Here, we report the results of nanopore translocation experiments and molecular dynamics simulations that provide insight into the impact of this modification on the structure and dyna...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4797264/ https://ncbi.nlm.nih.gov/pubmed/26578595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1199 |
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