Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors

Current therapeutic strategies for sickle cell anemia are aimed at reactivating fetal hemoglobin. Pomalidomide, a third-generation immunomodulatory drug, was proposed to induce fetal hemoglobin production by an unknown mechanism. Here, we report that pomalidomide induced a fetal-like erythroid diffe...

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Foilsithe in:Blood
Main Authors: Dulmovits, Brian M., Appiah-Kubi, Abena O., Papoin, Julien, Hale, John, He, Mingzhu, Al-Abed, Yousef, Didier, Sebastien, Gould, Michael, Husain-Krautter, Sehba, Singh, Sharon A., Chan, Kyle W. H., Vlachos, Adrianna, Allen, Steven L., Taylor, Naomi, Marambaud, Philippe, An, Xiuli, Gallagher, Patrick G., Mohandas, Narla, Lipton, Jeffrey M., Liu, Johnson M., Blanc, Lionel
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2016
Ábhair:
Red Cells, Iron, and Erythropoiesis
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4797024/
https://ncbi.nlm.nih.gov/pubmed/26679864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-09-667923
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