Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancers

BACKGROUND: The aim of the study was to explore Fc mutations of a humanised anti-Lewis-Y antibody (IgG1) hu3S193 as a strategy to improve therapeutic ratios for therapeutic payload delivery. METHODS: Four hu3S193 variants (I253A, H310A, H435A and I253A/H310A) were generated via site-directed mutagen...

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Detalhes bibliográficos
Publicado no:EJNMMI Res
Main Authors: Burvenich, Ingrid J. G., Lee, Fook-Thean, O’Keefe, Graeme J., Makris, Dahna, Cao, Diana, Gong, Sylvia, Rigopoulos, Angela, Allan, Laura C., Brechbiel, Martin W., Liu, Zhanqi, Ramsland, Paul A., Scott, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4796444/
https://ncbi.nlm.nih.gov/pubmed/26983636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-016-0180-0
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