Cross-species analysis of Fc engineered anti-Lewis-Y human IgG1 variants in human neonatal receptor transgenic mice reveal importance of S254 and Y436 in binding human neonatal Fc receptor

IgG has a long half-life through engagement of its Fc region with the neonatal Fc receptor (FcRn). The FcRn binding site on IgG1 has been shown to contain I253 and H310 in the CH2 domain and H435 in the CH3 domain. Altering the half-life of IgG has been pursued with the aim to prolong or reduce the...

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Publicado no:MAbs
Main Authors: Burvenich, Ingrid J. G., Farrugia, William, Lee, Fook T., Catimel, Bruno, Liu, Zhanqi, Makris, Dahna, Cao, Diana, O'Keefe, Graeme J., Brechbiel, Martin W., King, Dylan, Spirkoska, Violeta, Allan, Laura C., Ramsland, Paul A., Scott, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966839/
https://ncbi.nlm.nih.gov/pubmed/27030023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1156285
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