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De novo identification of replication-timing domains in the human genome by deep learning

Motivation: The de novo identification of the initiation and termination zones—regions that replicate earlier or later than their upstream and downstream neighbours, respectively—remains a key challenge in DNA replication. Results: Building on advances in deep learning, we developed a novel hybrid a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Bioinformatics
Hauptverfasser: Liu, Feng, Ren, Chao, Li, Hao, Zhou, Pingkun, Bo, Xiaochen, Shu, Wenjie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4795613/
https://ncbi.nlm.nih.gov/pubmed/26545821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btv643
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