Amino Acid Substitutions That Affect Receptor Binding and Stability of the Hemagglutinin of Influenza A/H7N9 Virus

Receptor-binding preference and stability of hemagglutinin have been implicated as crucial determinants of airborne transmission of influenza viruses. Here, amino acid substitutions previously identified to affect these traits were tested in the context of an A/H7N9 virus. Some combinations of subst...

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Bibliographic Details
Published in:J Virol
Main Authors: Schrauwen, Eefje J. A., Richard, Mathilde, Burke, David F., Rimmelzwaan, Guus F., Herfst, Sander, Fouchier, Ron A. M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Genetic Diversity and Evolution
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794686/
https://ncbi.nlm.nih.gov/pubmed/26792744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03052-15
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