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An assessment of computational methods for estimating purity and clonality using genomic data derived from heterogeneous tumor tissue samples
Solid tumor samples typically contain multiple distinct clonal populations of cancer cells, and also stromal and immune cell contamination. A majority of the cancer genomics and transcriptomics studies do not explicitly consider genetic heterogeneity and impurity, and draw inferences based on mixed...
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| Publié dans: | Brief Bioinform |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4794615/ https://ncbi.nlm.nih.gov/pubmed/24562872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bib/bbu002 |
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