Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency

Attenuated auto-lysosomal system has been associated with Alzheimer disease (AD), yet all underlying molecular mechanisms leading to this impairment are unknown. We show that the amino acid sensing of mechanistic target of rapamycin complex 1 (mTORC1) is dysregulated in cells deficient in presenilin...

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Publicado en:Cell Rep
Autores principales: Reddy, Kavya, Cusack, Corey L., Nnah, Israel C., Khayati, Khoosheh, Saqcena, Chaitali, Huynh, Tuong B., Noggle, Scott A., Ballabio, Andrea, Dobrowolski, Radek
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4793148/
https://ncbi.nlm.nih.gov/pubmed/26923592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.02.006
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