Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency

Attenuated auto-lysosomal system has been associated with Alzheimer disease (AD), yet all underlying molecular mechanisms leading to this impairment are unknown. We show that the amino acid sensing of mechanistic target of rapamycin complex 1 (mTORC1) is dysregulated in cells deficient in presenilin...

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Pubblicato in:Cell Rep
Autori principali: Reddy, Kavya, Cusack, Corey L., Nnah, Israel C., Khayati, Khoosheh, Saqcena, Chaitali, Huynh, Tuong B., Noggle, Scott A., Ballabio, Andrea, Dobrowolski, Radek
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4793148/
https://ncbi.nlm.nih.gov/pubmed/26923592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.02.006
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