Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency

Attenuated auto-lysosomal system has been associated with Alzheimer disease (AD), yet all underlying molecular mechanisms leading to this impairment are unknown. We show that the amino acid sensing of mechanistic target of rapamycin complex 1 (mTORC1) is dysregulated in cells deficient in presenilin...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Reddy, Kavya, Cusack, Corey L., Nnah, Israel C., Khayati, Khoosheh, Saqcena, Chaitali, Huynh, Tuong B., Noggle, Scott A., Ballabio, Andrea, Dobrowolski, Radek
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4793148/
https://ncbi.nlm.nih.gov/pubmed/26923592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.02.006
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