IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inflammation. Through basic and translational approaches involving murine models and human genetic epidemiology, we show here the importance of the different inflammasomes in regulating inflammatory resp...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Iannitti, Rossana G., Napolioni, Valerio, Oikonomou, Vasilis, De Luca, Antonella, Galosi, Claudia, Pariano, Marilena, Massi-Benedetti, Cristina, Borghi, Monica, Puccetti, Matteo, Lucidi, Vincenzina, Colombo, Carla, Fiscarelli, Ersilia, Lass-Flörl, Cornelia, Majo, Fabio, Cariani, Lisa, Russo, Maria, Porcaro, Luigi, Ricciotti, Gabriella, Ellemunter, Helmut, Ratclif, Luigi, De Benedictis, Fernando Maria, Talesa, Vincenzo Nicola, Dinarello, Charles A., van de Veerdonk, Frank L., Romani, Luigina
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4793079/
https://ncbi.nlm.nih.gov/pubmed/26972847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10791
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