IL-37 Inhibits Inflammasome Activation and Disease Severity in Murine Aspergillosis

Since IL-37 transgenic mice possesses broad anti-inflammatory properties, we assessed whether recombinant IL-37 affects inflammation in a murine model of invasive pulmonary aspergillosis. Recombinant human IL-37 was injected intraperitoneally into mice prior to infection and the effects on lung infl...

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Udgivet i:PLoS Pathog
Main Authors: Moretti, Silvia, Bozza, Silvia, Oikonomou, Vasilis, Renga, Giorgia, Casagrande, Andrea, Iannitti, Rossana G., Puccetti, Matteo, Garlanda, Cecilia, Kim, Soohyun, Li, Suzhao, van de Veerdonk, Frank L., Dinarello, Charles A., Romani, Luigina
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223056/
https://ncbi.nlm.nih.gov/pubmed/25375146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004462
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