mTOR kinase inhibitor pp242 causes mitophagy terminated by apoptotic cell death in E1A-Ras transformed cells

mTOR is a critical target for controlling cell cycle progression, senescence and cell death in mammalian cancer cells. Here we studied the role of mTOR-dependent autophagy in implementating the antiprolifrative effect of mTORC1-specific inhibitor rapamycin and ATP-competitive mTOR kinase inhibitor p...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Gordeev, Serguei A., Bykova, Tatiana V., Zubova, Svetlana G., Bystrova, Olga A., Martynova, Marina G., Pospelov, Valery A., Pospelova, Tatiana V.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792600/
https://ncbi.nlm.nih.gov/pubmed/26636543
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