Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers

Cells respond to genotoxic stress by activating the DNA damage response (DDR). When injury is severe or irreparable, cells induce apoptosis or cellular senescence to prevent transmission of the lesions to the daughter cells upon cell division. Resistance to apoptosis is a hallmark of cancer that cha...

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Detalhes bibliográficos
Main Authors: Chitikova, Zhanna V, Gordeev, Serguei A, Bykova, Tatiana V, Zubova, Svetlana G, Pospelov, Valery A, Pospelova, Tatiana V
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050140/
https://ncbi.nlm.nih.gov/pubmed/24626185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.28402
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