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Expression profiling reveals transcriptional regulation by Fbxw7/mTOR pathway in radiation-induced mouse thymic lymphomas

The tumor suppressor gene FBXW7 is deleted and mutated in many different types of human cancers. FBXW7 primarily exerts its tumor suppressor activity by ubiquitinating different oncoproteins including mTOR. Here we used gene transcript profiling to gain a deeper understanding of the role of FBXW7 in...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Snijders, Antoine M., Liu, Yueyong, Su, Li, Huang, Yurong, Mao, Jian-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792592/
https://ncbi.nlm.nih.gov/pubmed/26575021
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