The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo

ATR and ATM are DNA damage signaling kinases that phosphorylate several thousand substrates. ATR kinase activity is increased at damaged replication forks and resected DNA double-strand breaks (DSBs). ATM kinase activity is increased at DSBs. ATM has been widely studied since ataxia telangiectasia i...

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Vydáno v:Oncotarget
Hlavní autoři: Vendetti, Frank P., Lau, Alan, Schamus, Sandra, Conrads, Thomas P., O'Connor, Mark J., Bakkenist, Christopher J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792557/
https://ncbi.nlm.nih.gov/pubmed/26517239
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