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Structural Analysis on the Pathologic Mutant Glucocorticoid Receptor Ligand-Binding Domains
Glucocorticoid receptor (GR) gene mutations may cause familial or sporadic generalized glucocorticoid resistance syndrome. Most of the missense forms distribute in the ligand-binding domain and impair its ligand-binding activity and formation of the activation function (AF)-2 that binds LXXLL motif-...
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Publicado no: | Mol Endocrinol |
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Main Authors: | , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Endocrine Society
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4792232/ https://ncbi.nlm.nih.gov/pubmed/26745667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2015-1177 |
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