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Structural Analysis on the Pathologic Mutant Glucocorticoid Receptor Ligand-Binding Domains

Glucocorticoid receptor (GR) gene mutations may cause familial or sporadic generalized glucocorticoid resistance syndrome. Most of the missense forms distribute in the ligand-binding domain and impair its ligand-binding activity and formation of the activation function (AF)-2 that binds LXXLL motif-...

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Bibliografiske detaljer
Udgivet i:Mol Endocrinol
Main Authors: Hurt, Darrell E., Suzuki, Shigeru, Mayama, Takafumi, Charmandari, Evangelia, Kino, Tomoshige
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792232/
https://ncbi.nlm.nih.gov/pubmed/26745667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2015-1177
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