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Glucocorticoid Receptor Mutants Demonstrate Increased Motility Inside the Nucleus of Living Cells: Time of Fluorescence Recovery After Photobleaching (FRAP) Is an Integrated Measure of Receptor Function

Natural mutations of the human glucocorticoid receptor (GR) isoform α cause the glucocorticoid resistance syndrome. Mutant receptors may have abnormal interactions with the ligand, target DNA sequences, and/or multiple intracellular proteins, as well as aberrant nucleocytoplasmic trafficking. Using...

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Autori principali: Kino, Tomoshige, Liou, Szu-Heng, Charmandari, Evangelia, Chrousos, George P
Natura: Artigo
Lingua:Inglês
Pubblicazione: ScholarOne 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1431369/
https://ncbi.nlm.nih.gov/pubmed/16307173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/2005-00026.Kino
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