Targeting melanoma with immunoliposomes coupled to anti-MAGE A1 TCR-like single-chain antibody

Therapy of melanoma using T-cells with genetically introduced T-cell receptors (TCRs) directed against a tumor-selective cancer testis antigen (CTA) NY-ESO1 demonstrated clear antitumor responses in patients without side effects. Here, we exploited the concept of TCR-mediated targeting through intro...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Nanomedicine
Hauptverfasser: Saeed, Mesha, van Brakel, Mandy, Zalba, Sara, Schooten, Erik, Rens, Joost AP, Koning, Gerben A, Debets, Reno, ten Hagen, Timo LM
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2016
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792179/
https://ncbi.nlm.nih.gov/pubmed/27022262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S96123
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