A probabilistic generative model for quantification of DNA modifications enables analysis of demethylation pathways

We present a generative model, Lux, to quantify DNA methylation modifications from any combination of bisulfite sequencing approaches, including reduced, oxidative, TET-assisted, chemical-modification assisted, and methylase-assisted bisulfite sequencing data. Lux models all cytosine modifications (...

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Detalles Bibliográficos
Publicado en:Genome Biol
Main Authors: Äijö, Tarmo, Huang, Yun, Mannerström, Henrik, Chavez, Lukas, Tsagaratou, Ageliki, Rao, Anjana, Lähdesmäki, Harri
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2016
Assuntos:
Method
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792102/
https://ncbi.nlm.nih.gov/pubmed/26975309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-0911-6
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