Intrinsically active variants of Erk oncogenically transform cells and disclose unexpected autophosphorylation capability that is independent of TEY phosphorylation

The receptor-tyrosine kinase (RTK)/Ras/Raf pathway is an essential cascade for mediating growth factor signaling. It is abnormally overactive in almost all human cancers. The downstream targets of the pathway are members of the extracellular regulated kinases (Erk1/2) family, suggesting that this fa...

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Udgivet i:Mol Biol Cell
Main Authors: Smorodinsky-Atias, Karina, Goshen-Lago, Tal, Goldberg-Carp, Anat, Melamed, Dganit, Shir, Alexei, Mooshayef, Navit, Beenstock, Jonah, Karamansha, Yael, Darlyuk-Saadon, Ilona, Livnah, Oded, Ahn, Natalie G., Admon, Arie, Engelberg, David
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791124/
https://ncbi.nlm.nih.gov/pubmed/26658610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-07-0521
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