Intrinsically active variants of Erk oncogenically transform cells and disclose unexpected autophosphorylation capability that is independent of TEY phosphorylation

The receptor-tyrosine kinase (RTK)/Ras/Raf pathway is an essential cascade for mediating growth factor signaling. It is abnormally overactive in almost all human cancers. The downstream targets of the pathway are members of the extracellular regulated kinases (Erk1/2) family, suggesting that this fa...

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Bibliografiset tiedot
Julkaisussa:Mol Biol Cell
Päätekijät: Smorodinsky-Atias, Karina, Goshen-Lago, Tal, Goldberg-Carp, Anat, Melamed, Dganit, Shir, Alexei, Mooshayef, Navit, Beenstock, Jonah, Karamansha, Yael, Darlyuk-Saadon, Ilona, Livnah, Oded, Ahn, Natalie G., Admon, Arie, Engelberg, David
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Cell Biology 2016
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791124/
https://ncbi.nlm.nih.gov/pubmed/26658610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-07-0521
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