Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template

Genetic mutations or engineered nucleases that disrupt the HIV co-receptor CCR5 block HIV infection of CD4(+) T cells. These findings have motivated the engineering of CCR5-specific nucleases for application as HIV therapies. The efficacy of this approach relies on efficient biallelic disruption of...

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Vydáno v:Sci Transl Med
Hlavní autoři: Sather, Blythe D., Romano Ibarra, Guillermo S., Sommer, Karen, Curinga, Gabrielle, Hale, Malika, Khan, Iram F., Singh, Swati, Song, Yumei, Gwiazda, Kamila, Sahni, Jaya, Jarjour, Jordan, Astrakhan, Alexander, Wagner, Thor A., Scharenberg, Andrew M., Rawlings, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4790757/
https://ncbi.nlm.nih.gov/pubmed/26424571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac5530
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