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Functional Compensation of a Detrimental Amino Acid Substitution in a Cytotoxic-T-Lymphocyte Epitope of Influenza A Viruses by Comutations

Influenza A viruses accumulate amino acid substitutions in cytotoxic-T-lymphocyte (CTL) epitopes, allowing these viruses to escape from CTL immunity. The arginine-to-glycine substitution at position 384 of the viral nucleoprotein is associated with escape from CTLs. Introduction of the R384G substit...

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Udgivet i:J Virol
Principais autores: Rimmelzwaan, G. F., Berkhoff, E. G. M., Nieuwkoop, N. J., Fouchier, R. A. M., Osterhaus, A. D. M. E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2004
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC479054/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15280506/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.16.8946-8949.2004
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