Functional Compensation of a Detrimental Amino Acid Substitution in a Cytotoxic-T-Lymphocyte Epitope of Influenza A Viruses by Comutations

Influenza A viruses accumulate amino acid substitutions in cytotoxic-T-lymphocyte (CTL) epitopes, allowing these viruses to escape from CTL immunity. The arginine-to-glycine substitution at position 384 of the viral nucleoprotein is associated with escape from CTLs. Introduction of the R384G substit...

Full description

Saved in:
Bibliographic Details
Main Authors: Rimmelzwaan, G. F., Berkhoff, E. G. M., Nieuwkoop, N. J., Fouchier, R. A. M., Osterhaus, A. D. M. E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC479054/
https://ncbi.nlm.nih.gov/pubmed/15280506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.16.8946-8949.2004
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items