Virus Persistence in an Animal Model of Multiple Sclerosis Requires Virion Attachment to Sialic Acid Coreceptors

Persistent Theiler's virus infection in the central nervous system (CNS) of mice provides a highly relevant animal model for multiple sclerosis. The low-neurovirulence DA strain uses sialic acid as a coreceptor for cell binding before establishing infection. During adaptation of DA virus to gro...

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Main Authors: Kumar, A. S. Manoj, Reddi, Honey V., Kung, Aisha Y., Dal Canto, Mauro, Lipton, Howard L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC479047/
https://ncbi.nlm.nih.gov/pubmed/15280494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.16.8860-8867.2004
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