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Heparan Sulfate-Independent Infection Attenuates High-Neurovirulence GDVII Virus-Induced Encephalitis
The high-neurovirulence Theiler's murine encephalomyelitis virus (TMEV) strain GDVII uses heparan sulfate (HS) as a coreceptor to enter target cells. We report here that GDVII virus adapted to growth in HS-deficient cells exhibited two amino acid substitutions (R3126L and N1051S) in the capsid...
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Main Authors: | , , , , , |
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פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
American Society for Microbiology
2004
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נושאים: | |
גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC479051/ https://ncbi.nlm.nih.gov/pubmed/15280499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.16.8909-8916.2004 |
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