Heparan Sulfate-Independent Infection Attenuates High-Neurovirulence GDVII Virus-Induced Encephalitis

The high-neurovirulence Theiler's murine encephalomyelitis virus (TMEV) strain GDVII uses heparan sulfate (HS) as a coreceptor to enter target cells. We report here that GDVII virus adapted to growth in HS-deficient cells exhibited two amino acid substitutions (R3126L and N1051S) in the capsid...

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Detalhes bibliográficos
Main Authors: Reddi, Honey V., Kumar, A. S. Manoj, Kung, Aisha Y., Kallio, Patricia D., Schlitt, Brian P., Lipton, Howard L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC479051/
https://ncbi.nlm.nih.gov/pubmed/15280499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.16.8909-8916.2004
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