Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells

Mutations in the metabolic enzyme isocitrate dehydrogenase (IDH) have recently been identified as drivers in the development of several tumor types. Most notably, cytosolic IDH1 is mutated in 70–90% of low-grade gliomas and upgraded glioblastomas, and mitochondrial IDH2 is mutated in ~20% of acute m...

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Udgivet i:Front Oncol
Main Authors: Viswanath, Pavithra, Chaumeil, Myriam M., Ronen, Sabrina M.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Oncology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789800/
https://ncbi.nlm.nih.gov/pubmed/27014635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2016.00060
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