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Discovery of 3-Substituted 1H-Indole-2-carboxylic Acid Derivatives as a Novel Class of CysLT(1) Selective Antagonists
[Image: see text] The indole derivative, 3-((E)-3-((3-((E)-2-(7-chloroquinolin-2yl)vinyl)phenyl)amino)-3-oxoprop-1-en-1-yl)-7-methoxy-1H-indole-2-carboxylic acid (17k), was identified as a novel and highly potent and selective CysLT(1) antagonist with IC(50) values of 0.0059 ± 0.0011 and 15 ± 4 μM f...
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| 出版年: | ACS Med Chem Lett |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2016
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4789669/ https://ncbi.nlm.nih.gov/pubmed/26985325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00482 |
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