Characterization of molecular and cellular phenotypes associated with a heterozygous CNTNAP2 deletion using patient-derived hiPSC neural cells

Neurodevelopmental disorders, such as autism spectrum disorders and schizophrenia, are complex disorders with a high degree of heritability. Genetic studies have identified several candidate genes associated with these disorders, including contactin-associated protein-like 2 (CNTNAP2). Traditionally...

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Veröffentlicht in:NPJ Schizophr
Hauptverfasser: Lee, Inkyu S, Carvalho, Claudia M B, Douvaras, Panagiotis, Ho, Seok-Man, Hartley, Brigham J, Zuccherato, Luciana W, Ladran, Ian G, Siegel, Arthur J, McCarthy, Shane, Malhotra, Dheeraj, Sebat, Jonathan, Rapoport, Judith, Fossati, Valentina, Lupski, James R, Levy, Deborah L, Brennand, Kristen J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
Schlagworte:
Brief Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789165/
https://ncbi.nlm.nih.gov/pubmed/26985448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npjschz.2015.19
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