Inflammation perturbs the IL-7 axis, promoting senescence and exhaustion that broadly characterize immune failure in treated HIV infection

BACKGROUND: HIV-infected patients who fail to normalize CD4 T cells despite suppressive antiretroviral therapy have impaired immune homeostasis: diminished naïve T cell numbers, elevated T cell turnover, senescence and inflammation. METHODS: Blood samples from immune failures (n=60), immune successe...

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Detalhes bibliográficos
Publicado no:J Acquir Immune Defic Syndr
Main Authors: Shive, Carey L, Clagett, Brian, McCausland, Marie R, Mudd, Joseph C, Funderburg, Nicholas T, Freeman, Michael L, Younes, Souheil, Ferrari, Brian M, Rodriguez, Benigno, McComsey, Grace A, Calabrese, Leonard H, Sieg, Scott F, Lederman, Michael M
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788576/
https://ncbi.nlm.nih.gov/pubmed/26627102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000000913
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