Inflammation perturbs the IL-7 axis, promoting senescence and exhaustion that broadly characterize immune failure in treated HIV infection

BACKGROUND: HIV-infected patients who fail to normalize CD4 T cells despite suppressive antiretroviral therapy have impaired immune homeostasis: diminished naïve T cell numbers, elevated T cell turnover, senescence and inflammation. METHODS: Blood samples from immune failures (n=60), immune successe...

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Detaylı Bibliyografya
Yayımlandı:J Acquir Immune Defic Syndr
Asıl Yazarlar: Shive, Carey L, Clagett, Brian, McCausland, Marie R, Mudd, Joseph C, Funderburg, Nicholas T, Freeman, Michael L, Younes, Souheil, Ferrari, Brian M, Rodriguez, Benigno, McComsey, Grace A, Calabrese, Leonard H, Sieg, Scott F, Lederman, Michael M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788576/
https://ncbi.nlm.nih.gov/pubmed/26627102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000000913
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