Inflammation perturbs the IL-7 axis, promoting senescence and exhaustion that broadly characterize immune failure in treated HIV infection

BACKGROUND: HIV-infected patients who fail to normalize CD4 T cells despite suppressive antiretroviral therapy have impaired immune homeostasis: diminished naïve T cell numbers, elevated T cell turnover, senescence and inflammation. METHODS: Blood samples from immune failures (n=60), immune successe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Acquir Immune Defic Syndr
Prif Awduron: Shive, Carey L, Clagett, Brian, McCausland, Marie R, Mudd, Joseph C, Funderburg, Nicholas T, Freeman, Michael L, Younes, Souheil, Ferrari, Brian M, Rodriguez, Benigno, McComsey, Grace A, Calabrese, Leonard H, Sieg, Scott F, Lederman, Michael M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788576/
https://ncbi.nlm.nih.gov/pubmed/26627102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000000913
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