Preclinical Toxicity Evaluation of a Novel Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Administered via Intracerebral Convection-Enhanced Delivery in Rats

D2C7-(scdsFv)-PE38KDEL (D2C7-IT) is a novel immunotoxin that reacts with wild-type epidermal growth factor receptor (EGFRwt) and mutant EGFRvIII proteins overexpressed in glioblastomas. This study assessed the toxicity of intracerebral administration of D2C7-IT to support an initial Food and Drug Ad...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Invest New Drugs
Main Authors: Bao, Xuhui, Chandramohan, Vidyalakshmi, Reynolds, Randall P., Norton, John N., Wetsel, William C., Rodriguiz, Ramona M., Aryal, Dipendra K., McLendon, Roger E., Levin, Edward D., Petry, Neil A., Zalutsky, Michael R., Burnett, Bruce K., Kuan, Chien-Tsun, Pastan, Ira H., Bigner, Darell D.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788550/
https://ncbi.nlm.nih.gov/pubmed/26728879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-015-0318-3
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker