Molecular Basis for Cooperative Binding of Anionic Phospholipids to the PH Domain of the Arf GAP ASAP1

We have defined the molecular basis for association of the PH domain of the Arf GAP ASAP1 with phospholipid bilayers. Structures of the unliganded and dibutyryl PtdIns(4,5)P(2)-bound PH domain were solved. PtdIns(4,5)P(2) made contact with both a canonical site (C site) and an atypical site (A site)...

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Publicat a:Structure
Autors principals: Jian, Xiaoying, Tang, Wai-Kwan, Zhai, Peng, Roy, Neeladri Sekhar, Luo, Ruibai, Gruschus, James M., Yohe, Marielle E., Chen, Pei-Wen, Li, Yifei, Byrd, R. Andrew, Xia, Di, Randazzo, Paul A.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788500/
https://ncbi.nlm.nih.gov/pubmed/26365802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.08.008
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