Morphine-Induced Preconditioning: Involvement of Protein Kinase A and Mitochondrial Permeability Transition Pore

BACKGROUND: Morphine induces myocardial preconditioning (M-PC) via activation of mitochondrial large conductance Ca(2+)-sensitive potassium (mK(Ca)) channels. An upstream regulator of mK(Ca) channels is protein kinase A (PKA). Furthermore, mK(Ca) channel activation regulates mitochondrial bioenerget...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Dorsch, Marianne, Behmenburg, Friederike, Raible, Miriam, Blase, Dominic, Grievink, Hilbert, Hollmann, Markus W., Heinen, André, Huhn, Ragnar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788451/
https://ncbi.nlm.nih.gov/pubmed/26968004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0151025
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