The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes

The PHB-domain protein podocin maintains the renal filtration barrier and its mutation is an important cause of hereditary nephrotic syndrome. Podocin and its Caenorhabditis elegans orthologue MEC-2 have emerged as key components of mechanosensitive membrane protein signalling complexes. Whereas pod...

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Publicado en:Hum Mol Genet
Main Authors: Rinschen, Markus M., Bharill, Puneet, Wu, Xiongwu, Kohli, Priyanka, Reinert, Matthäus J., Kretz, Oliver, Saez, Isabel, Schermer, Bernhard, Höhne, Martin, Bartram, Malte P., Aravamudhan, Sriram, Brooks, Bernard R., Vilchez, David, Huber, Tobias B., Müller, Roman-Ulrich, Krüger, Marcus, Benzing, Thomas
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4787903/
https://ncbi.nlm.nih.gov/pubmed/26792178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw016
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