Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses

RNA viruses encode an RNA-dependent RNA polymerase (RdRp) that catalyzes the synthesis of their RNA(s). In the case of positive-stranded RNA viruses belonging to the order Nidovirales, the RdRp resides in a replicase subunit that is unusually large. Bioinformatics analysis of this non-structural pro...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Lehmann, Kathleen C., Gulyaeva, Anastasia, Zevenhoven-Dobbe, Jessika C., Janssen, George M. C., Ruben, Mark, Overkleeft, Hermen S., van Veelen, Peter A., Samborskiy, Dmitry V., Kravchenko, Alexander A., Leontovich, Andrey M., Sidorov, Igor A., Snijder, Eric J., Posthuma, Clara C., Gorbalenya, Alexander E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4787807/
https://ncbi.nlm.nih.gov/pubmed/26304538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv838
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