Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter

HIV-1 escapes antiretroviral agents by integrating into the host DNA and forming a latent transcriptionally silent HIV-1 provirus. Transcriptional activation is prerequisite for reactivation and the eradication of latent HIV-1 proviruses. dCas9-SunTag-VP64 transcriptional system has been reported th...

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Vydáno v:Mol Ther
Hlavní autoři: Ji, Haiyan, Jiang, Zhengtao, Lu, Panpan, Ma, Li, Li, Chuan, Pan, Hanyu, Fu, Zheng, Qu, Xiying, Wang, Pengfei, Deng, Junxiao, Yang, Xinyi, Wang, Jianhua, Zhu, Huanzhang
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786936/
https://ncbi.nlm.nih.gov/pubmed/26775808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.7
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