Potent and Targeted Activation of Latent HIV-1 Using the CRISPR/dCas9 Activator Complex

HIV-1 provirus integration results in a persistent latently infected reservoir that is recalcitrant to combined antiretroviral therapy (cART) with lifelong treatment being the only option. The “shock and kill” strategy aims to eradicate latent HIV by reactivating proviral gene expression in the cont...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Saayman, Sheena M, Lazar, Daniel C, Scott, Tristan A, Hart, Jonathan R, Takahashi, Mayumi, Burnett, John C, Planelles, Vicente, Morris, Kevin V, Weinberg, Marc S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786915/
https://ncbi.nlm.nih.gov/pubmed/26581162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.202
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