Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice

Increasing evidence suggests that Rho family GTPases could have a critical role in the biology of T-cell lymphoma. In ALK-rearranged anaplastic large cell lymphoma (ALCL), a specific subtype of T-cell lymphoma, the Rho family GTPases Cdc42 and Rac1 are activated by the ALK oncogenic activity. In vit...

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Bibliographic Details
Published in:Blood
Main Authors: Choudhari, Ramesh, Minero, Valerio Giacomo, Menotti, Matteo, Pulito, Roberta, Brakebusch, Cord, Compagno, Mara, Voena, Claudia, Ambrogio, Chiara, Chiarle, Roberto
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2016
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786839/
https://ncbi.nlm.nih.gov/pubmed/26747246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-11-683052
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