Direct Interaction between the Voltage Sensors Produces Cooperative Sustained Deactivation in Voltage-gated H(+) Channel Dimers

The voltage-gated H(+) channel (Hv) is a voltage sensor domain-like protein consisting of four transmembrane segments (S1–S4). The native Hv structure is a homodimer, with the two channel subunits functioning cooperatively. Here we show that the two voltage sensor S4 helices within the dimer directl...

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Vydáno v:J Biol Chem
Hlavní autoři: Okuda, Hiroko, Yonezawa, Yasushige, Takano, Yu, Okamura, Yasushi, Fujiwara, Yuichiro
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786727/
https://ncbi.nlm.nih.gov/pubmed/26755722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.666834
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