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Soluble Oligomers of the Pore-forming Toxin Cytolysin A from Escherichia coli Are Off-pathway Products of Pore Assembly

The α-pore-forming toxin Cytolysin A (ClyA) is responsible for the hemolytic activity of various Escherichia coli and Salmonella enterica strains. Soluble ClyA monomers spontaneously assemble into annular dodecameric pore complexes upon contact with membranes or detergent. At ClyA monomer concentrat...

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Publicado en:J Biol Chem
Autores principales: Roderer, Daniel, Benke, Stephan, Schuler, Benjamin, Glockshuber, Rudi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786705/
https://ncbi.nlm.nih.gov/pubmed/26757820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.700757
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