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Soluble Oligomers of the Pore-forming Toxin Cytolysin A from Escherichia coli Are Off-pathway Products of Pore Assembly

The α-pore-forming toxin Cytolysin A (ClyA) is responsible for the hemolytic activity of various Escherichia coli and Salmonella enterica strains. Soluble ClyA monomers spontaneously assemble into annular dodecameric pore complexes upon contact with membranes or detergent. At ClyA monomer concentrat...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Roderer, Daniel, Benke, Stephan, Schuler, Benjamin, Glockshuber, Rudi
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786705/
https://ncbi.nlm.nih.gov/pubmed/26757820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.700757
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