Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy

Overexpression of the oncoprotein mortalin in cancer cells and its protein partners enables mortalin to promote multiple oncogenic signaling pathways and effectively antagonize chemotherapy-induced cell death. A UBX-domain-containing protein, UBXN2A, acts as a potential mortalin inhibitor. This curr...

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Veröffentlicht in:Cell Stress Chaperones
Hauptverfasser: Sane, Sanam, Abdullah, Ammara, Nelson, Morgan E., Wang, Hongmin, Chauhan, Subhash C., Newton, Samuel S., Rezvani, Khosrow
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Netherlands 2015
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786526/
https://ncbi.nlm.nih.gov/pubmed/26634371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-015-0661-5
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