Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy

Overexpression of the oncoprotein mortalin in cancer cells and its protein partners enables mortalin to promote multiple oncogenic signaling pathways and effectively antagonize chemotherapy-induced cell death. A UBX-domain-containing protein, UBXN2A, acts as a potential mortalin inhibitor. This curr...

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Dettagli Bibliografici
Pubblicato in:Cell Stress Chaperones
Autori principali: Sane, Sanam, Abdullah, Ammara, Nelson, Morgan E., Wang, Hongmin, Chauhan, Subhash C., Newton, Samuel S., Rezvani, Khosrow
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Netherlands 2015
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786526/
https://ncbi.nlm.nih.gov/pubmed/26634371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-015-0661-5
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