Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells

Mortalin (mot-2) induces inactivation of the tumor suppressor p53's transcriptional and apoptotic functions by cytoplasmic sequestration of p53 in select cancers. The mot-2-dependent cytoprotective function enables cancer cells to support malignant transformation. Abrogating the p53-mot-2 inter...

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Detalhes bibliográficos
Main Authors: Sane, S, Abdullah, A, Boudreau, D A, Autenried, R K, Gupta, B K, Wang, X, Wang, H, Schlenker, E H, Zhang, D, Telleria, C, Huang, L, Chauhan, S C, Rezvani, K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973214/
https://ncbi.nlm.nih.gov/pubmed/24625977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.100
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