Amsacrine analog-loaded solid lipid nanoparticle to resolve insolubility for injection delivery: characterization and pharmacokinetics

Amsacrine analog is a novel chemotherapeutic agent that provides potentially broad antitumor activity when compared to traditional amsacrine. However, the major limitation of amsacrine analog is that it is highly lipophilic, making it nonconductive to intravenous administration. The aim of this stud...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Fang, Yi-Ping, Chuang, Chih-Hung, Wu, Pao-Chu, Huang, Yaw-Bin, Tzeng, Cherng-Chyi, Chen, Yeh-Long, Liu, Ya-Ting, Tsai, Yi-Hung, Tsai, Ming-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786061/
https://ncbi.nlm.nih.gov/pubmed/27019595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S97161
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